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Key messages

  • Recommendations for syphilis testing during pregnancy have changed to align with new national guidance - Syphilis – CDNA National Guidelines for Public Health Units
  • Congenital syphilis has re-emerged in Victoria since 2017, with 18 cases notified between 2017 and 2024. 
  • Congenital syphilis can result in stillbirth, prematurity and other adverse consequences in an affected baby. 
  • The new recommendation is for all pregnant women to be tested for syphilis three times during pregnancy; at the first antenatal visit, at 26-28 weeks and at 36 weeks or birth (whichever is earlier). 
  • Neonates should not be discharged without confirming that the mother’s syphilis status has been documented at least once during pregnancy. 
  • This is a change from the previous risk-based testing regime in pregnancy, which required a single syphilis test at the first antenatal visit and additional tests only for women who may be at high risk of sexually transmissible infections (STI). 
  • Pregnant woman at any gestation presenting with signs and symptoms of an STI, or who is a contact of a person with an STI, should be tested for syphilis. 
  • Syphilis can be treated with long acting (benzathine) penicillin. 
  • Preventing congenital syphilis requires vigilance, active treatment and follow-up.

Safer Care Victoria is distributing this Victorian Chief Health Officer Advisory:

Changes to syphilis testing during pregnancy

Get in touch

Clinical Guidance Team
Safer Care Victoria

Version history

First published: February 2025

To be reviewed: January 2028

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